The primary goal of our research is to understand how the process of production and differentiation of blood and immune cells is normally regulated.
We are interested how defects in this regulation can lead to blood cancers such as leukemia and lymphoma and other diseases of the blood including neutropenia, myelodysplastic syndrome and platelet deficiencies.
In our research program, we focus on the role of transcription factors and epigenetic regulators that can modify chromatin and gene expression programs
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About the Moroy Laboratory
The Moroy Lab – the “Hematopoiesis and Cancer Research Unit” at the IRCM aims to understand how the production and differentiation of hematopoietic and immune cells are normally regulated and how defects in this regulation can lead to leukemia and lymphoma and other hematopoietic diseases including rare blood disorders.
Research projects
The primary goal of our research is to understand how the production and differentiation of hematopoietic and immune cells are normally regulated and how defects in this regulation can lead to leukemia and lymphoma and other hematopoietic diseases including rare blood disorders. Our projects are :
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The RNA Helicase DDX3X - B cell development - B cell lymphoma
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The GFI1/LSD1 Complex in Myeloid Differentiation and Acute Myeloid Leukemia
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MYC and MIZ-1 in Lymphoid Development and Lymphomagenesis
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Long Non-Coding RNAs (lncRNAs) in Leukemia and Lymphoma