The primary goal of our research is to understand how the process of production and differentiation of blood and immune cells is normally regulated.
We are interested how defects in this regulation can lead to blood cancers such as leukemia and lymphoma and other diseases of the blood including neutropenia, myelodysplastic syndrome and platelet deficiencies.
In our research program, we focus on the role of transcription factors and epigenetic regulators that can modify chromatin and gene expression programs
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About the Moroy Laboratory
The Moroy Lab – the “Hematopoiesis and Cancer Research Unit” at the IRCM aims to understand how the production and differentiation of hematopoietic and immune cells are normally regulated and how defects in this regulation can lead to leukemia and lymphoma and other hematopoietic diseases including rare blood disorders.
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- February 17, 2017
We observed that a subgroup of patients with myelodysplastic syndrome (MDS) carrying a gene variant of the transcriptional repressor GFI1 (GFI136N) is more resistant to treatment […]- Date
- February 18, 2017
Lymphoma and leukemia are both cancers of blood cells, blood cell precursors or even blood stem cells that are programmed to form blood cells. While a […]- Date
- March 7, 2017
In leukemia, a form of blood cancer, cells from the bone marrow multiply without control and invade the bloodstream and other organs. This compromises the function […]- Date
- March 7, 2017
When cells are subjected to gamma irradiation or certain chemotherapeutic drugs, the chromosomes and in particular the DNA within the chromosomes are damaged. As a consequence, […]- Date
- March 7, 2017
Gfi1 is participating in the early steps of pro-T cell and a number of target genes have been identified for Gfi1 such as Id1, 2, both […]- Date
- March 7, 2017
Platelets are essential for blood clotting and are formed in the bone marrow by large cells, so-called “megakaryocytes”, which form long protrusions that penetrate into blood […]
May 4, 2018
Thursday, April 12, 2018 The Moroylab discovers a mechanism how the GFI1 protein facilitates DNA repair The Moroylab reveals how the GFI1 protein sometimes helps leukemia […]